Chir-124
Web124 reviews of San Marcos Chiropractic "Being not even able to walk due to my sciatic nerve going out my dear friend took pitty on me and gave … WebFeb 1, 2007 · CHIR-124 is a selective, quinolone-based CHK1 inhibitor that is structurally unrelated to other known CHK1 inhibitors [95]. CHIR-124 interacted synergistically with …
Chir-124
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WebAN Tse et al. CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo. Clin. Cancer Res. 2007, 13, 591-602. Y Tao et al. Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints. Cell Cycle. 2009, 8(8), 1196-205. JL Smith. WebCHIR-124. CHIR-124 is a novel and potent Chk1 inhibitor with IC50. MK-8776 (SCH 900776) MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2. PF-477736.
WebCHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC 50 = 0.3 nM in vitro ). 1 It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher … WebCHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.
WebCHIR124 is a potent and selective inhibitor of checkpoint kinase 1 (Chk1) ( IC50 = 0.3 nM) that produces G2-M abrogation which induces chemosensitisation. It also inhibits PDGFR and FLT3 (IC50 = 6.6 nM and 5.8 nM respectively). CHIR-124 inhibits Pgp activity in multidrug-resistant cell lines KB-V1 and A2780-Pac-Res. Safety Information 保管分類 … WebZentralbl Chir. 1999;124(5):W43-52. [Article in German] Authors W Timmermann 1 , W Hamelmann, A Thiede. Affiliation 1 Chirurgische Klinik und Poliklinik, Universitätsklinikum Würzburg. PMID: 10420536 No abstract available. MeSH terms Humans ...
WebJan 25, 2024 · To address this question, Cdc25A mACh/mACh cells (clone 8) were pre-treated with DMSO or IAA for 2 h and then incubated with 0–750 nM CHIR-124 for a further 3 days ( Fig. S4C ). Prior degradation of Cdc25A did not completely recover the growth inhibition caused by CHIR-124 treatment ( Fig. S4D ).
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