WebThe largest of these initiation factors, the eIF3 complex, organizes a web of interactions among several eIFs that assemble on the 40S subunit and participate in the different reactions involved in translation. ... Structural analysis suggests that eIF3 performs this scaffolding function by binding to the 40S subunit on its solvent-exposed ... WebJul 29, 2024 · Protein synthesis is principally regulated by variations in the translation initiation mechanism, whereby multiple eukaryotic initiation factors (eIF1 through 6) …
Eukaryotic translation initiation factor 3 plays distinct …
WebDec 1, 2011 · A structural and functional understanding of eIF3’s roles in human translation initiation has relied on human eIF3 purified from human cell lines (19–21), expressed in part in insect cells (3, 21, 22), or by comparison to eIF3 purified from other mammalian sources (18, 23).Human eIF3 purified from human cell lines was used to derive a low-resolution … WebNot all m6A readers are YTH containing; they also include eukaryotic initiation factor 3 (eIF3), heterogeneous nuclear ribonucleoproteins (HNRNPs), and insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs). eIF3 plays a role in translation preinitiation and has also been confirmed to bind preferentially to m6A within the 5'UTR of mRNA … the logical statement
Regulation and function of poised mRNAs in lymphocytes
WebApr 13, 2024 · This review discusses the functions of the m6A modification on RNAs, its role in cancer cell metabolic pathways, the possible underlying mechanisms of its effects and the implication of this modification in cancer therapy. ... Eukaryotic initiation factor 3 (eIF3) is an essential component for initiating cap-independent translation under basal ... WebDec 9, 2005 · During the process of translation preinitiation, eIF3 associates with a large complex of proteins called the preinitiation complex (PIC), which includes the small ribosomal subunit. eIF3 is composed of 13 subunits, … The eIF4F complex is composed of three subunits: eIF4A, eIF4E, and eIF4G. Each subunit has multiple human isoforms and there exist additional eIF4 proteins: eIF4B and eIF4H. eIF4G is a 175.5-kDa scaffolding protein that interacts with eIF3 and the Poly(A)-binding protein (PABP), as well as the other members of the eIF4F complex. eIF4E recognizes and binds to the 5' cap structure of mRNA, while eIF4G binds PABP, which binds the poly(A) tail, potentially circula… tickets universal hollywood