Eif4a3 location

Author: krri

August undefined, 2024

WebABSTRACT. EIF4A3 (eukaryotic translation initiation factor 4A3) is an RNA helicase and core component of the exon junction complex. While this RNA-binding protein (RBP) is well-characterized for its crucial roles in splicing, RNA trafficking and nonsense-mediated decay, its role in the regulation of metabolic signaling pathways remains elusive. WebAug 4, 2024 · Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction complex, is essential for splicing, mRNA trafficking, and nonsense …

EIF4A3 eukaryotic translation initiation factor 4A3 [Homo sapiens ...

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in WebChr Location 17q25.3; chr17:80135214-80147183 (-) GRCh38.p7. Alliance of Genome Resources. Eif4a3 ... J:242590 Miller EE, et al., EIF4A3 deficient human iPSCs and … employee motivation in health care

EIF4A3-induced circFIP1L1 represses miR-1253 and promotes

WebThe City of Fawn Creek is located in the State of Kansas. Find directions to Fawn Creek, browse local businesses, landmarks, get current traffic estimates, road conditions, and … WebMay 5, 2024 · Our findings indicate that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis. Background Primary liver cancer is currently the sixth most commonly diagnosed cancer and the third leading cause of cancer mortality worldwide [ 1 ]. WebBy using this site, you agree to our Terms and Conditions Got it! employee motivation during covid 19 pandemic

EIF4A3 CRISPR guide RNA, eukaryotic translation initiation factor …

hsa_circ_0030042 inhibits ox-LDL induced abnormal

WebThe following gRNA sequences were designed by Feng Zhang’s laboratory at the Broad institute* to uniquely target the EIF4A3 gene within the human genome. These gRNA sequences are for use with WT SpCas9, or as crRNA for use with WT SpCas9 protein, to introduce a DSB for genome editing. WebAug 5, 2024 · In a new study published in Science Advances, researchers at Karolinska Institutet have investigated the protein eIF4A3 and its role in the growth of cancer cells. The study shows that by... employee motivation incentivesWebDec 12, 2024 · YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1 ... difficult to obtain anatomic location features, which reduces the sensitivity of cytological and pathological diagnosis methods. As a result, most patients … drawback regulations 190

"WebeIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses. Viral infection activates the type I interferons (IFNs) and cellular antiviral responses. … " - Eif4a3 location

Eif4a3 location

eIF4A3 regulates the TFEB-mediated transcriptional …

WebIn vitro EIF4A3-silencing (or pharmacological inhibition) resulted in reduced aggressiveness, and hindered xenograft-tumours growth in vivo, whereas EIF4A3 overexpression increased tumour aggressiveness. EIF4A3-silencing altered the expression and splicing of key HCC-related genes, specially FGFR4. WebApr 7, 2024 · The peGFP-eIF4A3, peGFP-MLN51 and peGFP-Dcp1a vectors were a kind gift from Dr Catherine Tomasetto and Dr Fabienne Mauxion (IGBMC, Illkirch, France). The translation inhibitor cycloheximide (CHX) was purchased from Sigma and used at the concentration of 100 μg/ml. The nucleotide analogs 5-aza-2′-deoxycytidine (5-azadC) …

Did you know?

WebeIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC 50 =0.26 μM; K d =0.043 μM), which binds to a non-ATP binding site of eIF4A3 and … WebProteini. Full gene name according to HGNC. Eukaryotic translation initiation factor 4A3. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. EIF4A3 (DDX48, EIF4AIII, Fal1, KIAA0111) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Read more.

WebJan 3, 2024 · Abstract Eukaryotic initiation factor 4A-3 (EIF4A3) is a core component of the exon junction complex (EJC). Abnormalities in EIF4A3 are associated with carcinogenesis. The present study aimed to determine the biological role of EIF4A3 in hepatocellular carcinoma (HCC). Our study is based on the analysis of HCC sequencing data from … WebMay 30, 2024 · The most frequently identified central nervous system tumor in adults is glioblastoma multiforme (GBM). GBM prognosis remains poor despite multimodal treatment, i.e., surgery and radiation therapy with concurrent temozolomide-based chemotherapy. Silvestrol, an eIF4A inhibitor, has been demonstrated to be able to kill tumor cells in …

WebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of … WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn …

WebAug 11, 2024 · EIF4A3, a member of the DEAD-box protein family, is a nuclear matrix protein and a core component of the exon junction complex (EJC). Under physiological …

WebEIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway. The exon junction complex core factor eIF4A3 is a key … employee moonlightingWebMar 2, 2024 · Furthermore, we found that EIF4A3 could induce circPRKCI expression and nuclear export. Our findings revealed a novel regulating mechanism of EIF4A3/circPRKCI/miR-545-3p/WBP2/AKT axis in TNBC,... employee motivation news articlesWebB & C. Relative protein level of FOXO1, beclin1, eIF4A3, and LC3B in ox-LDL treated HUVECs. One-way ANOVA. Compared with 0 h, ***p < 0.001. n ≥ 6. D -F. Overexpression of hsa_circ_0030042 in HUVECs. drawback rejected merchandiseWebDownload scientific diagram hsa_circ_0030042 inhibits excessive autophagy through obstructing the recruitment of eIF4A3 to beclin1 and FOXO1 mRNA. A & B. Stable hsa_circ_0030042 overexpression ... drawback refundWebAug 11, 2024 · EIF4A3, a member of the DEAD-box protein family, is a nuclear matrix protein and a core component of the exon junction complex (EJC). Under physiological conditions, EIF4A3 participates in post-transcriptional gene regulation by promoting EJC control of precursor mRNA splicing, thus influencing nonsense-mediated mRNA decay. employee motivation maslow\u0027s theoryWebDec 13, 2024 · EIF4A3-induced circBRWD3 promotes tumorigenesis of breast cancer through miR-142-3p_miR-142-5p/RAC1/PAK1 signaling. Meng X, Li W, Meng Z, Li YMeng X, et al. BMC Cancer, 2024 Nov 28. PMID 36443711; Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation … employee motivation peer review journalsWebSingle cell type specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. … employee motivation scholarly articles