WebSystemic lupus erythematosus is an autoimmune disease attributing to a combination of genetic and environmental factors. Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 (IRF7). Weba–f DSS (2.5% for 6 days) was administered to induce a colitis model in Carinh WT and Carinh KO mice (a).Colitis was monitored by body weight loss (b), evaluated based on colonoscopy images (c ...
Interferon regulatory factor-7 modulates experimental …
WebThe observed association might be attributable to its close proximity with interferon regulatory factor 7 ( IRF7 ), because the strong LD ( r2 = 0.94) between this disease-associated SNP and a 3′ UTR PHRF1 SNP (rs702966) is within 0.6-kb flanking region of the IRF7 gene (51). IRF7, similar to IRF5, is a transcription factor that can activate ... WebIRF7 is required for the production and amplification of the antiviral type I (IFN-α/β) and III (IFN-λ) IFNs. The patient's fibroblasts displayed impaired IFN-β and IFN-λ1 production in … theory suede jacket mens
IRF7 - Interferon regulatory factor 7 - Function
WebJul 4, 2013 · This is in contrast to murine IRF7, which acts as a master regulator of type I IFN production upon TLR7 and TLR9 stimulation in murine cells 22. Further studies will be needed to clarify the function of human IRF7 in type I IFN production in different human cell populations and how human IRF7 is involved in late type I IFN induction. WebIRF7 plays a major role in the amplification of IFNα production downstream of PRR activation; in most cell types IRF7 is induced by innate IFN priming, however, it is also constitutively expressed in plasmacytoid DCs, where it drives the rapid synthesis of large quantities of IFNα subtypes in response to toll-like receptor (TLR) activation. WebMar 26, 2015 · IRF7 can be activated by RIG-I recognition of IAV genomic RNA, resulting in C-terminal serine phosphorylation by the IKK-related kinases TBK1 and IKK-ε ( 11, 14 – 20 ). Wild-type IRF7 was phosphorylated upon overexpression of TBK1, as was F410V ( Fig. 1D ). theory style cropped tie trench summer silk