Webb28 maj 2012 · See all SIN1 primary antibodies Description Rabbit polyclonal to SIN1 Host species Rabbit Tested applications Suitable for: WB, IP, IHC-P more details Species reactivity Reacts with: Human … Webb11 aug. 2015 · Current knowledge of the structure and functions of Sin1 are summarized, focusing specifically on its protein interaction network and its roles in the mTOR pathway that could account for various cellular functions of mTOR in growth, metabolism, immunity and cancer. Expand 2 Highly Influenced PDF View 11 excerpts, cites background Save Alert
Sin1 promotes proliferation and invasion of prostate
Webb6 okt. 2006 · (B) SIN1 is required for multiple growth factor-mediated Akt-Ser473 phosphorylation independent of nutrient input. Wild-type or SIN1 −/− MEFs were starved of serum and by nutrient (in PBS for the last 90 min) and then restimulated as indicated. p-Akt Ser473, p-Akt Thr308, total Akt, p-ERK1/2, and tubulin were determined by immunoblotting. Webb11 aug. 2015 · SIN1 phosphorylation mediates a positive feedback loop between Akt and mTORC2 Summary The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is known about the regulation of mTORC2 itself. camp cedarledge mo
Metabolic regulation of T cell development by Sin1–mTORC2 is mediat…
WebbHere we report that phosphorylation of Sin1 at Thr 86 and Thr 398 suppresses mTORC2 kinase activity by dissociating Sin1 from mTORC2. Importantly, Sin1 phosphorylation, triggered by S6K or Akt, in a cellular context-dependent manner, inhibits not only insulin- or IGF-1-mediated, but also PDGF- or EGF-induced Akt phosphorylation by mTORC2, … WebbThe pathological Sin1-R81T mutation exhibited elevated oncogenic activity in part by bypassing Sin1 phosphorylation-mediated negative regulation of Akt-pS473. (a–c) … Webb29 okt. 2024 · Therefore, Sin1 serves as the key component to mediate the cross talk between physiological signals and proper mTORC2 function. Although mTOR and Rictor … camp chair oztrail