WebFeb 17, 2016 · Equipment and Processing Report. Effective design of the tablet core and the coating process can help prevent film coating problems. Film coatings on pharmaceutical tablets provide a broad range of functionalities, and the coating formulation and process are complex, with many variables. Figure 1 shows the variables associated with a pan ... WebProblems such as edge chipping and tablet-surface erosion problems can often be minimized by optimizing the tablet core shape. For example, minimizing the sharpness of tablet edges can also minimize the risk of edge chipping. Such a positive impact of tablet design can often be achieved by employing compound radius punches rather than the ...
Common Tablet Defects: Causes and Remedies
WebChipping Chipping is when the film-coated tablet becomes dented or chipped, typically around the tablet’s edges. A common cause of tablet chipping is excessive attrition during the coating process. To mitigate tablet chipping due to the coating formulation, increase your film hardness by boosting the molecular grade of the polymer solution. WebChipping Mottling Double press or impression Although there are several defects that affect the tablet making process, capping/laminating, hardness and sticking/picking are the … in a network my computer internet is slow
Common Problems in Tablet Manufacturing Thomas
WebDec 26, 2024 · The tablet has been tested against MIL-STD-810G standards for resisting moisture, dirt, temperature changes, and drops so it's ready to handle anything your work … WebJun 11, 2015 · Tablet friability testing <1216>, listed in the USP, measures the way tablets hold up under tumbling conditions. The stress of tumbling and resistance of chipping and abrasion is measured by the weight loss of the tablets, after testing. A weight loss of 1 percent or less is usually acceptable. This apparatus and operation is clearly defined in ... WebMay 16, 2024 · To reduce tablet edge chipping, coating process adjustments that might be considered include: Reformulating tablet core to reduce brittleness and increase robustness. Increasing compaction forces to reduce tablet friability. Refurbishing or replacement of damaged/worn tooling. Eliminating the tendencies for lamination to occur. dutching definition